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/ALNY
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Alnylam Pharmaceuticals Inc

Alnylam Pharmaceuticals Inc

ALNY
$267.47USD-5.54%-15.68 today

MARKET CAP

35.7B

P/E (TTM)

68.1x

FWD P/E

27.5x

DAY RANGE

$266 – $284

52W RANGE

$266
$496

AI Summary

Stalk
StalkMedium

ALNY remains in a Stage 4 decline yet qualifies for mean-reversion participation. Medium-term bias is set to Bullish on permission of a lower valuation bound and demand zone around multi-year lows. Short-term conditions remain neutral, with extreme oversold readings and price trading below declining EMAs. Execution should be deferred into stabilization and a reclaim of EMAs within the demand zone, as the active Support Failure pattern underlines continued downside risk without confirmation.

  • Q1 net revenue exceeded $1B, up 121% YoY; TTR franchise $910M (+153%).
  • Pipeline set to expand from 25 to over 40 trials, including Down syndrome–associated Alzheimer’s.
  • Earnings yield is negative, highlighting overvaluation concerns.
Full analysis →
Insider Trades84 trades
DateSideTickerInsiderRoleSharesPriceMkt Cap52W High52W LowValue% ChgRuleAI View
Apr 2, 2026SellALNYMelissa MclaughlinChief Human Resources Officer3,910$325.92$35.7B-46.03%+0.39%$1.3M-2.36%10b5-1Trim
Mar 4, 2026SellALNYKevin Joseph FitzgeraldCSO & EVP, Head of Research1,291$323.54$35.7B-46.03%+0.39%$417.7K-0.50%10b5-1Trim
Mar 4, 2026SellALNYTolga TangulerEVP, Chief Commercial Officer2,309$323.08$35.7B-46.03%+0.39%$746.0K-0.81%Trim
Mar 4, 2026SellALNYJeffrey V. PoultonEVP, Chief Financial Officer2,468$323.08$35.7B-46.03%+0.39%$797.4K-0.49%Trim
Mar 4, 2026SellALNYYvonne GreenstreetChief Executive Officer2,933$323.08$35.7B-46.03%+0.39%$947.6K-0.38%Trim
Mar 4, 2026SellALNYPushkal GargEVP Chief R&D4,713$323.53$35.7B-46.03%+0.39%$1.5M-1.80%10b5-1Trim
Mar 2, 2026SellALNYTolga TangulerEVP, Chief Commercial Officer1,598$327.65$35.7B-46.03%+0.39%$523.6K-0.42%Trim
Mar 2, 2026SellALNYJeffrey V. PoultonEVP, Chief Financial Officer2,206$327.65$35.7B-46.03%+0.39%$722.8K-0.33%Trim
Mar 2, 2026SellALNYKevin Joseph FitzgeraldCSO & EVP, Head of Research3,250$323.62$35.7B-46.03%+0.39%$1.1M-0.95%10b5-1Trim
Mar 2, 2026SellALNYPushkal GargEVP Chief R&D3,492$323.63$35.7B-46.03%+0.39%$1.1M-0.95%10b5-1Trim
Mar 2, 2026SellALNYYvonne GreenstreetChief Executive Officer6,799$327.65$35.7B-46.03%+0.39%$2.2M-0.59%Trim
Feb 27, 2026SellALNYPushkal GargEVP Chief R&D4,627$331.34$35.7B-46.03%+0.39%$1.5M-3.75%10b5-1Trim
Feb 13, 2026SellALNYTolga TangulerEVP, Chief Commercial Officer1,959$310.08$35.7B-46.03%+0.39%$607.4K-5.81%Trim
Feb 13, 2026SellALNYJeffrey V. PoultonEVP, Chief Financial Officer2,242$310.08$35.7B-46.03%+0.39%$695.2K-3.61%Trim
Feb 13, 2026SellALNYPushkal GargEVP Chief R&D2,242$310.08$35.7B-46.03%+0.39%$695.2K-8.28%Trim
Feb 13, 2026SellALNYKevin Joseph FitzgeraldCSO & EVP, Head of Research4,000$321.24$35.7B-46.03%+0.39%$1.3M-8.24%10b5-1Trim
Feb 13, 2026SellALNYYvonne GreenstreetChief Executive Officer6,958$310.08$35.7B-46.03%+0.39%$2.2M-7.51%Trim
Jan 12, 2026SellALNYTolga TangulerEVP, Chief Commercial Officer1,510$362.87$35.7B-46.03%+0.39%$547.9K-0.24%Trim
Jan 12, 2026SellALNYPushkal GargEVP Chief R&D1,510$362.87$35.7B-46.03%+0.39%$547.9K-0.31%Trim
Jan 12, 2026SellALNYJeffrey V. PoultonEVP, Chief Financial Officer2,780$362.87$35.7B-46.03%+0.39%$1.0M-0.23%Trim
Jan 12, 2026SellALNYKevin Joseph FitzgeraldCSO & EVP, Head of Research3,800$367.37$35.7B-46.03%+0.39%$1.4M-0.59%10b5-1Trim
Jan 12, 2026SellALNYYvonne GreenstreetChief Executive Officer9,577$362.86$35.7B-46.03%+0.39%$3.5M-0.55%Trim
Nov 26, 2025BuyALNYYvonne GreenstreetChief Executive Officer5,818$171.66$35.7B-46.03%+0.39%$998.7K+0.97%Trim
Nov 17, 2025SellALNYKevin Joseph FitzgeraldCSO & EVP, Head of Research20,289$318.21$35.7B-46.03%+0.39%$6.5M-1.34%10b5-1Trim
Nov 12, 2025SellALNYYvonne GreenstreetChief Executive Officer51,300$284.96$35.7B-46.03%+0.39%$14.6M+0.00%10b5-1Trim
Oct 2, 2025SellALNYTolga TangulerEVP, Chief Commercial Officer1,405$452.05$35.7B-46.03%+0.39%$635.1K-0.42%Trim
Oct 2, 2025SellALNYKevin Joseph FitzgeraldCSO & EVP, Head of Research2,441$452.05$35.7B-46.03%+0.39%$1.1M-0.77%Trim
Oct 2, 2025SellALNYJeffrey V. PoultonEVP, Chief Financial Officer3,821$452.05$35.7B-46.03%+0.39%$1.7M-0.57%Trim
Oct 2, 2025SellALNYPushkal GargEVP Chief R&D5,959$451.76$35.7B-46.03%+0.39%$2.7M-1.47%10b5-1Trim
Oct 2, 2025SellALNYYvonne GreenstreetChief Executive Officer8,924$452.05$35.7B-46.03%+0.39%$4.0M-1.06%Trim
Aug 29, 2025SellALNYTolga TangulerEVP, Chief Commercial Officer3,474$448.37$35.7B-46.03%+0.39%$1.6M-2.08%10b5-1Trim
Aug 18, 2025SellALNYKevin Joseph FitzgeraldCSO & EVP, Head of Research1,396$453.27$35.7B-46.03%+0.39%$632.8K-0.74%Trim
Aug 18, 2025SellALNYTolga TangulerEVP, Chief Commercial Officer1,396$453.27$35.7B-46.03%+0.39%$632.8K-0.57%Trim
Aug 18, 2025SellALNYJeffrey V. PoultonEVP, Chief Financial Officer2,274$453.27$35.7B-46.03%+0.39%$1.0M-0.55%Trim
Aug 18, 2025SellALNYPushkal GargEVP Chief R&D2,851$455.89$35.7B-46.03%+0.39%$1.3M-0.93%10b5-1Trim
Aug 18, 2025SellALNYYvonne GreenstreetChief Executive Officer6,979$453.27$35.7B-46.03%+0.39%$3.2M-1.43%Trim
May 30, 2025SellALNYYvonne GreenstreetChief Executive Officer101,874$211.78$35.7B-46.03%+0.39%$21.6M+0.00%10b5-1Trim
May 16, 2025SellALNYYvonne GreenstreetChief Executive Officer8,376$285.31$35.7B-46.03%+0.39%$2.4M-14.61%Trim
May 2, 2025SellALNYYvonne GreenstreetChief Executive Officer41,311$259.39$35.7B-46.03%+0.39%$10.7M-41.88%Trim
Mar 21, 2025SellALNYPushkal GargCMO & EVP Dev & Med Affairs15,211$203.46$35.7B-46.03%+0.39%$3.1M-6.14%10b5-1Trim
Mar 3, 2025SellALNYTolga TangulerEVP, Chief Commercial Officer471$243.78$35.7B-46.03%+0.39%$114.8K-0.27%Trim
Mar 3, 2025SellALNYJeffrey V. PoultonEVP, Chief Financial Officer1,264$243.78$35.7B-46.03%+0.39%$308.1K-0.36%Trim
Mar 3, 2025SellALNYPushkal GargCMO & EVP Dev & Med Affairs2,557$242.92$35.7B-46.03%+0.39%$621.2K-0.69%10b5-1Trim
Mar 3, 2025SellALNYKevin Joseph FitzgeraldCSO & EVP, Head of Research2,755$242.94$35.7B-46.03%+0.39%$669.3K-1.26%10b5-1Trim
Mar 3, 2025SellALNYYvonne GreenstreetChief Executive Officer3,877$243.79$35.7B-46.03%+0.39%$945.2K-0.53%Trim
Feb 28, 2025SellALNYKevin Joseph FitzgeraldCSO & EVP, Head of Research496$241.69$35.7B-46.03%+0.39%$119.9K-0.49%Trim
Feb 28, 2025SellALNYTolga TangulerEVP, Chief Commercial Officer513$241.68$35.7B-46.03%+0.39%$124.0K-0.43%Trim
Feb 28, 2025SellALNYJeffrey V. PoultonEVP, Chief Financial Officer796$241.70$35.7B-46.03%+0.39%$192.4K-0.29%Trim
Feb 28, 2025SellALNYPushkal GargCMO & EVP Dev & Med Affairs935$241.69$35.7B-46.03%+0.39%$226.0K-0.85%Trim
Feb 28, 2025SellALNYYvonne GreenstreetChief Executive Officer2,900$241.69$35.7B-46.03%+0.39%$700.9K-0.42%Trim
Feb 14, 2025SellALNYJeffrey V. PoultonEVP, Chief Financial Officer967$255.17$35.7B-46.03%+0.39%$246.7K-0.24%Trim
Feb 14, 2025SellALNYYvonne GreenstreetChief Executive Officer1,213$255.17$35.7B-46.03%+0.39%$309.5K-0.12%Trim
Feb 14, 2025SellALNYKevin Joseph FitzgeraldCSO & EVP, Head of Research2,103$252.71$35.7B-46.03%+0.39%$531.4K-0.87%10b5-1Trim
Feb 14, 2025SellALNYPushkal GargCMO & EVP Dev & Med Affairs3,109$253.43$35.7B-46.03%+0.39%$787.9K-1.28%10b5-1Trim
Jan 27, 2025SellALNYPushkal GargCMO & EVP Dev & Med Affairs101,468$190.56$35.7B-46.03%+0.39%$19.3M-3.10%10b5-1Trim
Dec 12, 2024SellALNYPushkal GargCMO & EVP Dev & Med Affairs1,752$251.00$35.7B-46.03%+0.39%$439.8K-1.51%10b5-1Trim
Nov 26, 2024SellALNYTolga TangulerEVP, Chief Commercial Officer1,469$250.98$35.7B-46.03%+0.39%$368.7K-2.07%Trim
Nov 26, 2024SellALNYJeffrey V. PoultonEVP, Chief Financial Officer1,682$250.98$35.7B-46.03%+0.39%$422.1K-1.06%Trim
Nov 26, 2024SellALNYPushkal GargCMO & EVP Dev & Med Affairs1,682$250.98$35.7B-46.03%+0.39%$422.1K-1.81%Trim
Nov 26, 2024SellALNYKevin Joseph FitzgeraldCSO & EVP, Head of Research3,000$251.65$35.7B-46.03%+0.39%$754.9K-2.27%10b5-1Trim
Nov 26, 2024SellALNYYvonne GreenstreetChief Executive Officer5,219$250.98$35.7B-46.03%+0.39%$1.3M-1.26%Trim
Aug 20, 2024SellALNYYvonne GreenstreetChief Executive Officer30,000$182.50$35.7B-46.03%+0.39%$5.5M+0.00%10b5-1Trim
Aug 12, 2024SellALNYKevin Joseph FitzgeraldCSO & EVP, Head of Research42,750$182.81$35.7B-46.03%+0.39%$7.8M-0.74%10b5-1Trim
Aug 1, 2024SellALNYYvonne GreenstreetChief Executive Officer30,296$177.50$35.7B-46.03%+0.39%$5.4M+0.00%10b5-1Trim
Jul 11, 2024SellALNYYvonne GreenstreetChief Executive Officer7,093$261.00$35.7B-46.03%+0.39%$1.9M-8.81%10b5-1Trim
Jun 25, 2024SellALNYKevin Joseph FitzgeraldCSO & EVP, Head of Research1,198$230.99$35.7B-46.03%+0.39%$276.7K-0.67%Trim
Jun 25, 2024SellALNYTolga TangulerEVP, Chief Commercial Officer1,605$231.00$35.7B-46.03%+0.39%$370.7K-1.05%Trim
Jun 25, 2024SellALNYJeffrey V. PoultonEVP, Chief Financial Officer1,605$231.00$35.7B-46.03%+0.39%$370.7K-0.45%Trim
Jun 25, 2024SellALNYPushkal GargCMO & EVP Dev & Med Affairs2,103$230.99$35.7B-46.03%+0.39%$485.8K-1.03%Trim
Jun 25, 2024SellALNYYvonne GreenstreetChief Executive Officer8,301$230.99$35.7B-46.03%+0.39%$1.9M-0.80%Trim
Feb 28, 2024SellALNYIndrani Lall FranchiniEVP, CLO & Secretary329$155.30$35.7B-46.03%+0.39%$51.1K-1.43%Trim
Feb 28, 2024SellALNYTolga TangulerEVP, Chief Commercial Officer501$155.30$35.7B-46.03%+0.39%$77.8K-1.65%Trim
Feb 28, 2024SellALNYPushkal GargCMO & EVP Dev & Med Affairs574$155.30$35.7B-46.03%+0.39%$89.1K-1.19%Trim
Feb 28, 2024SellALNYJeffrey V. PoultonEVP, Chief Financial Officer574$155.30$35.7B-46.03%+0.39%$89.1K-0.56%Trim
Feb 28, 2024SellALNYYvonne GreenstreetChief Executive Officer2,932$155.31$35.7B-46.03%+0.39%$455.4K-1.14%Trim
Feb 16, 2024SellALNYJeffrey V. PoultonEVP, Chief Financial Officer1,007$148.06$35.7B-46.03%+0.39%$149.1K-1.79%Trim
Feb 16, 2024SellALNYTolga TangulerEVP, Chief Commercial Officer1,009$148.06$35.7B-46.03%+0.39%$149.4K-7.22%Trim
Feb 16, 2024SellALNYPushkal GargCMO & EVP Dev & Med Affairs1,308$148.06$35.7B-46.03%+0.39%$193.7K-5.39%Trim
Feb 16, 2024SellALNYYvonne GreenstreetChief Executive Officer7,030$148.06$35.7B-46.03%+0.39%$1.0M-4.76%Trim
Feb 2, 2024SellALNYIndrani Lall FranchiniEVP, CLO & Secretary1,591$170.99$35.7B-46.03%+0.39%$272.1K-8.43%Trim
Aug 4, 2023SellALNYJeffrey V. PoultonEVP, Chief Financial Officer3,460$185.85$35.7B-46.03%+0.39%$643.0K-3.35%Trim
Aug 4, 2023SellALNYAkshay VaishnawPresident4,057$185.85$35.7B-46.03%+0.39%$754.0K-2.78%Trim
Aug 4, 2023SellALNYYvonne GreenstreetChief Executive Officer4,057$185.85$35.7B-46.03%+0.39%$754.0K-1.84%Trim
Aug 4, 2023SellALNYPushkal GargCMO & EVP Dev & Med Affairs7,627$184.78$35.7B-46.03%+0.39%$1.4M-9.82%10b5-1Trim