Lumida
/SYRE
⌘K
Spyre Therapeutics Inc

Spyre Therapeutics Inc

SYRE
$100.23USD+6.49%+6.11 today

MARKET CAP

8.7B

P/E (TTM)

FWD P/E

DAY RANGE

$92 – $101

52W RANGE

$15
$105

AI Summary

Stalk
StalkMedium

In a Stage 2 advance with a medium-term bullish bias confirmed by higher highs and rising EMAs, the recent bearish engulfing on a marginal new high signals buyer exhaustion and overbought stress. Price has rejected at the 9/21 EMA and is pulling back with elevated volume, making current levels unattractive for new longs. We defer buying until a disciplined pullback is absorbed near the rising EMA support zone to participate in the ongoing uptrend.

  • Mizuho raised its target from $84 to $120; SYRE hit 52-week high.
  • Pending SKYWAY study data could be key valuation catalyst.
  • Earnings yield at -1.67% reflects negative operating returns.
Full analysis →
Insider Trades22 trades
DateSideTickerInsiderRoleSharesPriceMkt Cap52W High52W LowValue% ChgRuleAI View
Jul 1, 2026SellSYREScott L BurrowsChief Financial Officer15,000$51.12$8.7B-4.62%+591.00%$766.8K+0.00%10b5-1Stalk
Jul 1, 2026SellSYRESheldon SloanChief Medical Officer16,668$57.58$8.7B-4.62%+591.00%$959.7K+0.00%10b5-1Stalk
Jul 1, 2026SellSYRECameron TurtleChief Executive Officer15,000$87.69$8.7B-4.62%+591.00%$1.3M-0.85%10b5-1Stalk
Jun 25, 2026SellSYREScott L BurrowsChief Financial Officer30,000$50.82$8.7B-4.62%+591.00%$1.5M+0.00%Stalk
Jun 3, 2026SellSYRESheldon SloanChief Medical Officer16,666$51.23$8.7B-4.62%+591.00%$853.8K+0.00%10b5-1Stalk
Jun 1, 2026SellSYREScott L BurrowsChief Financial Officer15,000$42.78$8.7B-4.62%+591.00%$641.7K+0.00%10b5-1Stalk
Jun 1, 2026SellSYRECameron TurtleChief Executive Officer15,000$70.43$8.7B-4.62%+591.00%$1.1M-0.82%10b5-1Stalk
May 1, 2026SellSYRECameron TurtleChief Executive Officer15,000$71.37$8.7B-4.62%+591.00%$1.1M-0.40%10b5-1Stalk
May 1, 2026SellSYREScott L BurrowsChief Financial Officer25,000$42.94$8.7B-4.62%+591.00%$1.1M+0.00%10b5-1Stalk
May 1, 2026SellSYRESheldon SloanChief Medical Officer156,666$49.48$8.7B-4.62%+591.00%$7.8M+0.00%10b5-1Stalk
Apr 1, 2026SellSYREScott L BurrowsChief Financial Officer15,000$31.92$8.7B-4.62%+591.00%$478.8K+0.00%10b5-1Stalk
Apr 1, 2026SellSYRESheldon SloanChief Medical Officer15,916$35.83$8.7B-4.62%+591.00%$570.3K+0.00%10b5-1Stalk
Apr 1, 2026SellSYRECameron TurtleChief Executive Officer15,000$49.33$8.7B-4.62%+591.00%$739.9K-1.18%10b5-1Stalk
Mar 3, 2026SellSYREScott L BurrowsChief Financial Officer5,000$27.57$8.7B-4.62%+591.00%$137.9K+0.00%10b5-1Stalk
Mar 2, 2026SellSYRECameron TurtleChief Executive Officer15,000$42.19$8.7B-4.62%+591.00%$632.9K-1.15%10b5-1Stalk
Feb 2, 2026SellSYRECameron TurtleChief Executive Officer15,000$32.80$8.7B-4.62%+591.00%$492.0K-1.12%10b5-1Stalk
Jan 2, 2026SellSYRECameron TurtleChief Executive Officer15,000$30.68$8.7B-4.62%+591.00%$460.1K-0.74%10b5-1Stalk
Dec 1, 2025SellSYRECameron TurtleChief Executive Officer15,000$29.02$8.7B-4.62%+591.00%$435.4K-1.08%10b5-1Stalk
Nov 3, 2025SellSYRECameron TurtleChief Executive Officer45,000$23.33$8.7B-4.62%+591.00%$1.0M-3.07%10b5-1Stalk
Sep 2, 2025SellSYREScott L BurrowsChief Financial Officer18,428$16.26$8.7B-4.62%+591.00%$299.6K-15.83%Stalk
Sep 3, 2024SellSYREScott L BurrowsChief Financial Officer18,531$28.17$8.7B-4.62%+591.00%$522.1K-13.73%Stalk
Feb 15, 2024BuySYRECameron TurtleChief Executive Officer400$9.82$8.7B-4.62%+591.00%$3.9K+0.05%16bStalk